GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs742132 | 1 | rs6908390 | chr6:25609756 | SCGN | chr6:25652429-25702006:+ | 0.3 | 5.92 | 6.13E-9 | Uric acid levels |
| THCA | cis | rs6909229 | 1 | rs6909229 | chr6:158572379 | SERAC1 | chr6:158530536-158589312:- | 0.25 | 5.1 | 4.98E-7 | Lipoprotein (a) levels |
| THCA | cis | rs6910233 | 1 | rs6910233 | chr6:33534726 | HLA-DPB2 | chr6:33080293-33096890:+ | 0.12 | 3.41 | 0.0007 | Chagas cardiomyopathy in Tripanosoma cruzi seropositivity |
| THCA | cis | rs6910233 | 1 | rs6910233 | chr6:33534726 | ZBTB9 | chr6:33422356-33425318:+ | -0.16 | -3.47 | 0.000577 | Chagas cardiomyopathy in Tripanosoma cruzi seropositivity |
| THCA | cis | rs6911965 | 1 | rs6910460 | chr6:24471712 | GMNN | chr6:24775159-24786276:+ | -0.28 | -3.81 | 0.000159 | Hematological and biochemical traits |
| THCA | cis | rs6911965 | 1 | rs6910460 | chr6:24471712 | GPLD1 | chr6:24428405-24489850:- | 0.25 | 4.7 | 3.49E-6 | Hematological and biochemical traits |
| THCA | cis | rs6911965 | 1 | rs6910460 | chr6:24471712 | MRS2 | chr6:24403153-24425809:+ | 0.24 | 5.47 | 7.34E-8 | Hematological and biochemical traits |
| THCA | cis | rs7769051 | 1 | rs6910639 | chr6:133120553 | C6orf192 | chr6:133090507-133119747:- | -0.25 | -4.1 | 4.87E-5 | Type 2 diabetes nephropathy |
| THCA | cis | rs1056667 | 1 | rs6910899 | chr6:26524339 | BTN2A3 | chr6:26422317-26431927:+ | 0.19 | 4.52 | 7.82E-6 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6910899 | chr6:26524339 | HCG11 | chr6:26521934-26527610:+ | -0.23 | -4.43 | 1.19E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6910899 | chr6:26524339 | HMGN4 | chr6:26538572-26547162:+ | -0.16 | -4.05 | 5.86E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6910899 | chr6:26524339 | ZNF322A | chr6:26634612-26659963:- | -0.14 | -3.77 | 0.00018 | Educational attainment |
| THCA | cis | rs6911965 | 1 | rs6911965 | chr6:24480295 | MRS2 | chr6:24403153-24425809:+ | -0.27 | -5.92 | 6.21E-9 | Hematological and biochemical traits |
| THCA | cis | rs7762018 | 1 | rs6912959 | chr6:170126224 | C6orf70 | chr6:170151721-170181617:+ | 0.25 | 5.08 | 5.39E-7 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs7762018 | 1 | rs6912959 | chr6:170126224 | WDR27 | chr6:169857307-170102159:- | -0.18 | -5.53 | 5.37E-8 | Thiazide-induced adverse metabolic effects in hypertensive patients |